LITERATURE REVIEW
LITERATURE REVIEW
Crude hypericum oblongifolium extract was studied for its
anti-nociceptive, antipyretic and inflammatory properties by Naila Raziq et al[1]. They conducted hot plate tests and in vivo acetic acid-induced
writhing experiments to determine the antinociceptive effects of 100,200 and
300mg/kgi.p. Yeast-induced hyperthermia and carrageenan-induced mouse paw edema
were used to investigate the anti-inflammatory and anti-pyretic properties of
methanol extracts, correspondingly. In numerous animal model, they discovered
that methanol extract of hypericum oblongifolium had notable anti-pyretic,
antinociceptive and anti-inflammatory properties.
Ghulam Abbas et al[2] investigated
the crude extracts of the two medicinally significant herbs hypericum
perforatum and hypericum oblongifolium, for their possible cytotoxicity
research, anti-lipid peroxidation, anti-glycation and antioxidant. They explore
that aqueous n-Butanol fraction of hypericum perforatum demonstrated
significant anti-oxidant potential in the 1,I-Diphenyl-2-picrylhydrazylradical
(DPPH) assay, with IC value 91.44±2.052 and 119.781±2.821 µg/ml . The n-Butanol
fraction of hypericum oblongifolium also demonstrated temperate activity with
IC value 215.375±3.562. In their study, inhibitory activities against protein
glycation were demonstrated by the n-butanol and n-hexane fractions,
respectively, at 57.250% and 50.018%.According to their research, both species,
aqueous and n-Butanol fractions exhibit favorable anti-oxidant and
anti-glycation capabilities in vitro with no harmful side effects.
Naila Raziq et al[3] studied phytochemicals research on hypericum oblongifolium caused
the ethyl acetate fraction of methanolic extract to be used to isolate the
flavones folicitin and a bicyclic conjugated lactone called folenolide. Based
on thorough spectroscopic research, both metabolites were classified as novel
substances by them. They used the 1,I-Diphenyl-2-picrylhydrazylradical (DPPH)
assay to asses both drugs in vitro anti-oxidant activity. They found that the compound
namely folicitin was active anti-oxidant while folenolide was sedentary.
A comprehensive study done by Shubhangi et al[4]
shows that a review of the literature for many papers, journals, and
traditional Indian medical materials state that Hypericum oblongifolium
contains a lot of therapeutic benefits. It is widely accepted that they have a
history of being used to cure conditions including stomach ulcer, snake bite
and respiratory disease. They found in
their study that several secondary metabolites from hypericum oblongifolium
show numerous medicinal properties like anti-microbial and anti-oxidant.
Using the common writhing test on mice, the analgesic efficacy of
the medicinal herb hypericum oblongifolium was examined experimentally by
Jamshed Ali et al[5]. According to their research, the plant has anti-inflammatory and analgesic
properties, which may be caused by the existence of flavonoids. In their
investigation, they did specify that it is important to check furthermore that,
if these medicinal herbs has any anti-inflammatory or narcotic properties.
Namdar Yousofvand et al[6] presented a review on hypericum oblongifolium and concluded that this
plant contain saponins flavonoids and tannis. Additionally, there are chemicals
substances including ramentine, myrcetin, kaempeferol and quecretin. Furthermore,
this plant has been linked to reports of peripheral anti-nociceptive and fever
and inflammation lowering properties[7].
Bahare Salehi et al[8] conducted a research on the phytochemiclas that have antidiabetic effects. According to their findings, the phytochemicals that can serve as anti-diabetic agents are phenolic acid, alkaloids, glycosides and flavonoids. They studied various animals studies in which numerous processes are outlined that account for phytochemiclas positive benefits, involving control of glucose metabolism, stimulation of β-cells, Reactive Oxygen Species (ROS) protection, Insulin production and NF-KB signaling pathway. They also presented the idea of treating diabetes mellitus (DM) with readily available plants-based chemicals that do not require complicated pharmaceutical production is quietly appealing.
Goncalo Infant Calderia et al[9] investigated and recorded 58 distinct hypericum plant species as potential for the organic compounds. They further noted the specific cytotoxicity of several hypericum species against inhibition of adipogensis, anti-Alzheimer, anti-microbial, anti-depressent, anti-inflammatory.
2. Abba, G., Non-to Inhibit pr.
4. Mehra, S. and A.N. Sah, HYPERICUM OBLONGIFOLIUM A REVIEW.
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